VIEWPOINTS

Vitamin C and Cancer

The Riordan Clinic is probably most famous for Dr. Riordan’s interest in furthering research on Linus Pauling’s original hypotheses that Vitamin C could be a potential cure for heart disease, chronic infections and even cancer.  His hypothesis was first developed some time in the 1950s and nearly 70 years later, it is still alive and well.  Researchers all over the world, including several prestigious universities here in the states are still very intrigued by Vitamin C.

 

Vitamin C Kills Tumor Cells With Hard-To-Treat Mutation

Maybe Linus Pauling was on to something after all. Decades ago the Nobel Prize–winning chemist was relegated to the fringes of medicine after championing the idea that vitamin C could combat a host of illnesses, including cancer. Now, a study published online today in Science reports that vitamin C can kill tumor cells that carry a common cancer-causing mutation and—in mice—can curb the growth of tumors with the mutation.

Gold Coasters injecting vitamin C directly into bloodstream to improve immune system

GETTING a needle at the doctor’s may be a sore point for some, but not for an ­increasing number of Gold Coasters who are injecting vitamin C directly into their bloodstream.

A Varsity Lakes doctor says there has been an increase in people opting for unconventional intravenous vitamin C therapy over ­taking traditional vitamins to improve the immune ­system and help with other conditions.

THE SCIENCE

Modulation of Cytokines in Cancer Patients by Intravenous Ascorbate Therapy

Nina Mikirova, Neil Riordan, Joseph Casciari

Background: Cytokines play an important role in tumor angiogenesis and inflammation. There is evidence in the literature that high doses of ascorbate can reduce inflammatory cytokine levels in cancer patients. The objective of this study was to investigate the effect of treatment by intravenous vitamin C (IVC) on cytokines and tumor markers.

 

Material/Methods: With the availability of protein array kits allowing assessment of many cytokines in a single sample, we measured 174 cytokines and additional 54 proteins and tumor markers in 12 cancer patients before and after a series of IVC treatments.

 

Results: Presented results show for our 12 patients the effect of treatment resulted in normalization of many cytokine levels. Cytokines that were most consistently elevated prior to treatments included M-CSF-R, Leptin, EGF, FGF-6, TNF-a, b, TARC, MCP-1,4, MIP, IL-4, 10, IL-4, and TGF-b. Cytokine levels tended to decrease during the course of treatment. These include mitogens (EGF, Fit-3 ligand, HGF, IGF-1, IL-21R) and chemo-attractants (CTAC, Eotaxin, E-selectin, Lymphotactin, MIP-1, MCP-1, TARC, SDF-1), as well as inflammation and angiogenesis factors (FGF-6, IL-1b, TGF-1).

 

Conclusions: We are able to show that average z-scores for several inflammatory and angiogenesis promoting cytokines are positive, indicating that they are higher than averages for healthy controls, and that their levels decreased over the course of treatment. In addition, serum concentrations of tumor markers decreased during the time period of IVC treatment and there were reductions in cMyc and Ras, 2 proteins implicated in being upregulated in cancer.

 

 

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